What We All Long For follows the overlapping stories of a close circle of second-generation twenty-somethings living in downtown Toronto. There’s Tuyen, a lesbian avant-garde artist and the daughter of Vietnamese parents who’ve never recovered from losing one of their children in the crush to board a boat out of Vietnam in the 1970s. Tuyen defines herself in opposition to just about everything her family believes in and strives for. She’s in love with her best friend Carla, a biracial bicycle courier, who’s still reeling from the loss of her mother to suicide eighteen years earlier and who must now deal with her brother Jamal’s latest acts of delinquency. Oku is a jazz-loving poet who, unbeknownst to his Jamaican-born parents, has dropped out of university. He is in constant conflict with his narrow-minded and verbally abusive father and tormented by his unrequited love for Jackie, a gorgeous black woman who runs a hip clothing shop on Queen Street West and dates only white men. Like each of her friends, Jackie feels alienated from her parents, former hipsters from Nova Scotia who never made it out of subsidized housing after their lives became entangled with desire and disappointment.

The four characters try to make a life for themselves in the city, supporting one another through their family struggles.