Mayor J. Jonah Jameson is in the midst of attempting to frame Spider-Man again, by showing footage of him with Doctor Octopus. However, reporters point out that there is direct evidence to the contrary and the Fantastic Four have given statements that exonerate him. Nevertheless, Jonah still wants to paint Spider-Man as a menace.

Meanwhile, Peter Parker is waking from a hard sleep, barley remembering what happened at his Aunt May's wedding, where he was reunited with Mary-Jane Watson. Flashes show him and Michele Gonzales separately getting drunk. By then, Peter had forgotten that he had slept with her. Michele storm into her bathroom, angry that Peter doesn't even remember. She shouts at him to get out.

As Peter goes on patrol as Spider-Man, he vividly remembers what happened before his hangover. He then turns his attention to a bank robber. Using his web-shooters, he pins the crook to a news stand, angering the proprietor.

Spidey then arrives at Aunt May's house, which he expects to be deserted due to Aunt May being on her honeymoon, enough for him to live in for a while. Unfortunately, the house is filled with his Reilly relatives. He then goes to meet with Harry Osborn, only to learn that his friend has moved out. His last resort was to ask Betty Brant for a place to live temporarily. However, Gloria Grant has already moved in due to the cutbacks on the DB. Then suddenly, Dexter Bennett comes out shouting that there is a fire at the Empire State Building.

Spidey is quickly on the scene. He manages to clear a path through the fire for the civilians by using the water pumps in the men's restroom. He then tells the fireman not to thank him, if they wish to avoid Jonah's wrath. A comment about Grand Central makes Spidey remember that he was suppose to meet up with MJ. However, apparently she had slept in as well. She turns on her TV, learning of Spider-Man's good deed. She comments that that he did a nice job.

Peter arrives back at Michele's apartment, apparently deserted. He finds a tray of cookies on the table, which he assumes to be a "peace offering", not noticing that the fridge has been chained up.