With great power comes great responsibility but what happens with unlimited cosmic power? When a science experiment goes wrong, Peter Parker's spider-powers are enhanced to an unbelievable degree! And the timing can't be beat - because with a cabal of deadly villains unleashing unpredictable attacks on Marvel's heroes, Spider-Man will need all his newfound power just to survive! But who or what is the real force behind Spidey's cosmic empowerment? And what is the battle he is destined to fight? Plus: Spider-Man teams up with the Punisher and deals with the return of Venom! COLLECTING: Amazing Spider-Man 326-333 & Annual 24, Spectacular Spider-Man 158-160 & Annual 10, Web of Spider-Man 59-61 & Annual 6.