The story opens with Spider-Man waking up to a phone call. When he answers, J. Jonah Jameson yells at him to get over to "Armstrong Park" to get pictures of a super villain. This is unusual, since Peter no longer works for J. Jonah Jameson. When he arrives at the park, Morlun is waiting for him, and kills him, saying "Why do I even bother explaining, when all you ever do is DIE?" It is then revealed that this is an alternate universe where humanity lives on the moon.

Later, on Earth-001, Morlun's family, the Inheritors, wait for him to return from his hunt. When he comes back, Daemos asks him what world's Spidey he killed this time, and Morlun responds by saying it doesn't matter. Verna says to keep telling himself that. She then decides to go on a hunt, and her servants fetch 3 of her hounds: Sable, Fireheart and Kravinoff (all resembling characters from Spider-Man's life),and tells the Master Weaver to bring her to a world with young Totems. After she leaves, Morlun asks his brother what she meant, and Daemos tells him that the whole family knows that Morlun has been avoiding a specific thread of the Great Web. Morlun says he has been saving it for last, and when Daemos considers hunting there himself Morlun tells him to stay away from it, and Daemos remembers it is Earth-616.

Our Spider-Man from Earth-616 wakes up to see Cindy Moon, aka Silk, hanging before him. She says she has a solution to their problem, which is that whenever they get close, they feel the need to mate because of their connection, having been bitten by the same spider. She says he should move to another city, jokingly suggesting the moon, and that she could handle New York.

They go outside and swing around the city. They then run into Looter, who has stolen a Spider-Tank and Spiderling outfits from Spider-Island II, Superior Spidey's base. After dealing with him, one of the henchmen flees from the scene. Suddenly, Spider-Woman, 616 Spider-Girl, and Spider-Man 2099 arrive. Miguel tells Peter that they need to talk.

The last remaining henchman is very confused, and is confronted by Spider-UK, MC2 Spider-Girl, and Spider-Ham, who knocks him out. Peter becomes becomes very confused, and Spider-Uk says that they are the Spiders of other dimensions and that all the strands of the Great Web are converging on him. Peter is shocked, but Mayday Parker, aka Spider-Girl, reminds him of the time they met before to calm him down and says that they need his help to stop the Inheritors. Spider-UK tells him Daemos, Morlun's elder brother, is coming to Earth-616, and all of them, including Silk, head into a portal to another dimension.

Meanwhile, in Eastern Europe, at the home of the New Warriors, Kaine Parker, aka Scarlet Spider, was beaten down by Daemos, who defeated the New Warriors. Kaine then stabs him through the chest with spikes coming from his arm and Daemos realized that unlike other spiders, he actually make him feel pain. He realizes that he is the current receptable of the Other, and says he would savour him for days.

Suddenly, Old Man Spider-Man, Bruce Banner Spider-Man and a mysterious Spider-Character appear through a portal to save him. The third Spider-Man turns out to be Gwen Stacy, aka Spider-Women of Earth-65. This shocks Kaine, and he thinks she is a clone and that the Jackal was behind it. Suddenly, Ben Reilly, the original Scarlet Spider, appears to help out. This surprises Kaine, because Ben Reilly was killed by the Green Goblin. Daemos then breakes Bruce Banner Spidey's spine and the others all escape through a portal.

Meanwhile, on Earth-13, a large group of Spider-Men are gathered. The group that saved Scarlet Spider arrive, and Peter can't process how Ben Reilly and Gwen Stacy are here. He then asks what was so special about this Earth. Suddenly, Cosmic Spider-Man arrives, and hands Mayday Parker her baby brother. Cosmic Spidey tells Peter that this is a world where he never lost the Enigma Force, and the Inheritors would be foolish to come there. However, he cannot leave his world or the Enigma Force would stay behind, but in the coming battle, he would go with them. Peter asks him what he means, and Spider-UK says there is a war coming, and they tell him he is the greatest of them all.

In the Ultimate Universe, Miles Morales is seen mourning the loss of his mother, and how he could have saved her. Ultimate Jessica Drew arrives and tells him that he shouldn't quit being Spider-Man. Miles says he isn't, but being Spider-Man cost him his family. Jessica says that he can make a new one, and that the Spiders need to stick together. Suddenly, Verna arrives from a portal to kill them, and says it's better for them to split up, because it's much better when they RUN!