After the events that transpired after Peter Parker's reveal as Spider-Man, Doctor Strange consults via Astral Plane to Tony Stark and Reed Richards about Peter's situation and request of the world forget he's Spider-Man. While the three of them discuss what happened during Civil War, they all agree that the best way to help Peter is to use a powerful combination of science and magic to make a worldwide mindwipe.

Strange arrives back to the Sanctum Sanctorum and asks Peter if he's sure to go along with the plan of the mindwipe which he agrees. Then Strange creates a forcefield to protect Peter from the effects so he can be the only one who retains the memories of all that transpired, but when the spell begins, he leaps out of the force field to bring Mary Jane along with him so she can remember everything as well. With the combined forces of Doctor Strange, Iron Man and Mr. Fantastic, the world has forgot that Peter Parker is Spider-Man.

After the spell effects, Peter wakes up next to Mary Jane in a motel room (the same one after Back in Black/One More Day). When MJ wakes up and Peter explains, she angrily confronts Peter claiming why he didn't let her forget too and now she has to carry on all the painful memories of their lives together with the dangers of Spider-Man's identity, but in the end they realize that their love is stronger, but can't let it be as long as Spider-Man remains active. After their talk, Peter returns to Aunt May's hospital room to check on her and after talking with the same nurse he asked to watch for her, he finds that the spell worked and nobody remembers his identity as Spider-Man.

Back in the present day, Mary Jane and Peter talk about everything that transpired and agree that the best way to remain together is to stay as the close friends they were when they first met and that he has to move on and find someone who can be with him both as Peter Parker and as Spider-Man.

In the end, Spidey reflects while web-swinging that the one person that has truly loved him has set him free and now he can face any challenge in front of him, making his life feel like a "Brand New Day"