After transforming the Lizard back to Curt Connors, Spider-Man, Morbius and the Horizon scientists bring him to Horizon Labs. Running a diagnostic on Connors, Modell confirms that every reptilian cell on Connors's body has been purged. Although Connors thanks Morbius for developing the cure that allowed him to become human again, he secretly plans to take vengeance on him. Spider-Man notes that Morbius is weakened. Through Morbius's gestures, Connors deduces that Morbius keeps a small storage of blood inside a fridge on the lab.

Modell believes that since the cure worked on Connors, they can use it on Morbius, but Spider-Man disagrees, inadvertently slipping Morbius's desecration of Billy Connors's corpse right in front of his father. Connors requests to see his son's body, and Morbius apologizes for digging up Billy's corpse, saying that he used Billy's DNA to develop a cure for his condition. Connors asks to be left alone for a moment, and the others leave the room. Alone in the lab, Connors takes one of the blood packs in the fridge and puts it on the ventilation system.

In the hallway, Spider-Man and Modell meet up with Hector and the other Horizon scientists. The Horizon team is shocked at Morbius, Sanjani says that she called Carlie Cooper to take care of Morbius. At that moment, a blood haze is released through the vent. Impulsed by the blood haze, Morbius bites Sanjani in the neck, shocking the others. Spider-Man attacks Morbius, who is shocked at his own actions. Morbius escapes the lab, and Spider-Man takes Uatu's vampire gear to chase him.

Connors comes into the hallway, telling the others they can cure Morbius. Carlie tells Connors he will have to turn himself to the police for his actions as the Lizard, and Connors agrees, but not before curing Morbius. Although Modell offers his help, Connors prefers to work alone.

Spider-Man and Morbius fight across the rooftops of New York City. Although Morbius tries to explain his actions, Spider-Man refuses to listen.

Meanwhile at Astoria, Queens, Julia Carpenter is taking her daughter Rachel to summer school. Suddenly, she has a vision, telling her that the great web is unravelling. Grabbing her Madame Web gear, Julia goes to warn Spider-Man.

As Modell and Connors work on the cure, Modell says that they will have to inject some of Connors's lizard formula into lab rats. Suddenly, Connors drops a syringe, and Modell picks up. But as soon as he gives it to Connors, he realizes Connors has regained his right arm. Connors beats Modell down and straps him to a table. He then injects him with the lizard formula, transforming him into a lizard. Eating one of the rats, Connors proclaims that he will be the Lizard again.